Enhanced in vivo antifungal activity of novel cell penetrating peptide natamycin conjugate for efficient fungal keratitis management

Harsha Rohira,Sujithra Shankar,Shikha Yadav,Sushmita G. Shah,Archana Chugh

International Journal of Pharmaceutics（2021）

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摘要

•Antifungal drug Natamycin covalently conjugated with a cell penetrating peptide Tat2.•Enhanced ocular penetration of the Tat2natamycin conjugate than natamycin alone.•Enhanced antifungal efficacy of Tat2natamycin against Fusarium dimerum.•Tat2nat is a promising therapeutic conjugate against fungal keratitis by F. dimerum.

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关键词

Cell penetrating peptides,Corneal diseases,Fungal keratitis,Fusarium sp.,Tat2natamycin

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