MicroRNA-877-5p alleviates ARDS via enhancing PI3K/Akt path by targeting CDKN1B both in vivo and in vitro

Kaili Li, Zuoting Huang,Shijing Tian,Yi Chen,Yuan Yuan,Jianghan Yuan,Xuan Zou,Fachun Zhou

International Immunopharmacology（2021）

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摘要

•LPS reduced miR-877-5p expression and caused HPMEC cell injury.•miR-877-5p protects the pulmonary microvascular endothelium barrier.•CDKN1B functioned as a target of miR-877-5p.•miR-877-5p facilitates PI3K/Akt signaling pathway probably through CDKN1B.

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关键词

microRNA-877-5p,(Acute respiratory distress syndrome) ARDS,(Cyclin-dependent kinase inhibitor 1B) CDKN1B,Cdk2,Endothelial barrier,PI3K/Akt signaling pathway

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