SINGLE OR MULTI-DOSE DELIVERY EAR TAG FOR VETERINARY APPLICATIONS

Williams Michael S, Li Jason Siu Wei, Coffey Jacob, Steiger Christoph Winfried Johannes, Jimenez Miguel,Langer Robert S, Caffarel Salvador Ester,Abramson Alex

user-5f8cf9244c775ec6fa691c99(2020)

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摘要
A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.
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关键词
Ear tag,Dermis,Epidermis (botany),Biomedical engineering,Medicine,Controlled delivery,Delivery system,Dose delivery,Multiple dosing
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