Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2

Dewang Fu,Ben Liu,Huamao Jiang,Zhaowei Li,Chenghui Fan,Li'e Zang

Genomics（2021）

Cited 8|Views2

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Abstract

•This study aims to elucidate the role of miR-19b-1-5p/ABL2 in bladder cancer.•Increased ABL2 and decreased miR-19b-1-5p are found in bladder cancer.•Restored exosomal miR-19b-1-5p restrained growth of bladder cancer cells.•Silenced ABL2 suppressed tumor growth of bladder cancer.•This study is essential for finding new therapeutic targets for bladder cancer.

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Key words

Bladder cancer,microRNA-19b-1-5p,Non-receptor protein tyrosine kinase Arg,Bone marrow mesenchymal stem cells,Proliferation,Apoptosis,Migration,Invasion

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