A Tapered-pulsed Fidaxomicin Regimen Following Treatment in Patients With Multiple Clostridioides difficile Infection Recurrences

Andrew M. Skinner,Xing Tan,Benjamin D. Sirbu,Larry H. Danziger,Dale N. Gerding,Stuart Johnson

CLINICAL INFECTIOUS DISEASES（2021）

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摘要

We treated 46 patients with multiple recurrent Clostridioides difficile infections (mrCDI) using a tapered-pulsed (T-P) fidaxomicin regimen, the majority of whom failed prior T-P vancomycin treatment. Sustained clinical response rates at 30 and 90 days were 74% (34/46) and 61% (28/46). T-P fidaxomicin shows promise for management of mrCDI.

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关键词

Clostridioides difficile,recurrent C. difficile infection,fidaxomicin,Oral Vancomycin

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