HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I
Molecular Immunology（2021）
Abstract
•HSPBP1 interacted with RIG-I and the interaction was enhanced upon virus infection.•HSPBP1 is a positive regulator of RLR signaling.•Knockdown or knockout of HSPBP1 inhibits RLR signaling.•HSPBP1 inhibits RIG-I K48-linked polyubiquitination to stabilize it and strengthen its cellular antiviral response.
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Key words
RIG-I,MAVS,IFN-β,HSPBP1,Ubiquitination,RLR signaling
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