Immunization with extracellular vesicles excreted by Toxoplasma gondii confers protection in murine infection, activating cellular and humoral responses

Marta Marques Maia,Allecineia Bispo da Cruz,Noemi Nosomi Taniwaki,Gislene Mitsue Namiyama,Ricardo Gava,Aparecida Helena Souza Gomes,Cristina Takami Kanamura,Maria Lourdes Peris Barbo,Vera Lucia Pereira-Chioccola

International Journal for Parasitology（2021）

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摘要

•This study evaluated Toxoplasma gondii extracellular vesicles (EVs) as immunogen.•Mice were immunized with purified tachyzoite EVs.•Mice immunized and challenged with a virulent strain had low parasitemia/mortality.•EVs were able to stimulate protective immunity in experimental mice.•EV immunization elicited high production of IgG1, IFN-γ, IL-10 and TNF-α.

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关键词

Toxoplasma gondii,Extracellular vesicles,Immunization,Cellular and humoral response

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