Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

Milad Ashrafizadeh,Masoud Delfi,Farid Hashemi,Amirhossein Zabolian,Hossein Saleki,Morteza Bagherian,Negar Azami,Mahdi Vasheghani Farahani,Seyed Omid Sharifzadeh,Soodeh Hamzehlou,Kiavash Hushmandi,Pooyan Makvandi,Ali Zarrabi,Michael R. Hamblin,Rajender S. Varma

Carbohydrate Polymers（2021）

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Abstract

•The linear polysaccharide, chitosan (CS), has applications in nanoparticle synthesis.•SiRNA is a genetic tool for suppressing molecular pathways in cancer inhibition.•CS-based nanoarchitectures can be utilized for siRNA delivery in cancer therapy.•SiRNA-loaded CS affects metastasis, and proliferation of cancer cells significantly.•CS nanoparticles can provide a platform for co-delivery of siRNA anti-tumor drugs.

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Key words

SiRNA,CS,PCL,RNAi,RISC,mRNA,PD-L1,mTOR,BBB,TPP,PEG,DS,PGA,CS-MNPs,PEI,HPV,IAP,IL-6,VEGF,TMC,TMC-CMD,IGF-1R,STAT3,MMPs,DTX,MUC1,HA,EMT,CXCR4,P-gp,MDR1,GC,LDR,EPR,EGFR,TERT,HTCC,PTX,DOX,ChNPs,MMP-9,HMGA2,CA,GO,CGO,PLGA

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