Developmental exposure to chlordecone induces transgenerational effects in somatic prostate tissue which are associated with epigenetic histone trimethylation changes

•Chlordecone exposure is associated with increased prostate cancer risk.•Chlordecone increases prostatic epithelial neoplasia in F1 and F3 mice.•In exposed mice, we observed alterations in histone H3K4me3.•Hoxa genes are affected both in the prostate and in sperm of F1 and F3 generations.