Direct anti-proliferative effect of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients on allogenic CD4+ cells.

Ewa Kuca-Warnawin,Magdalena Plebańczyk,Krzysztof Bonek,Ewa Kontny

Reumatologia（2021）

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摘要

AS/ASCs, similar to HD/ASCs, exert a direct effective anti-proliferative impact on CD4+ T cells, acting via soluble factors that are released in cell contact-dependent (IL-10) and independent (kynurenines, PGE-2) pathways. Thus, our results suggest that AS/ASCs are potentially useful for therapeutic application.

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关键词

T-cell proliferation,adipose-derived mesenchymal stem cells,ankylosing spondylitis,kynurenines

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