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SUMO-1在ApoE-/-小鼠PM2.5暴露中调控血管HIF-1α/VEGF信号通路的研究

Xiangdong GAN, Fei LI,Xin CAI,Wenliang FU,Donggang XU,Minhui LONG

Journal of South China Normal University（Natural Science Edition）（2017）

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Abstract
以气管滴注方法研究了ApoE-/-小鼠经PM2.5暴露后,其主动脉弓中SUMO-1、HIF-1α、血管内皮生长因子(VEGF)表达变化规律及HIF-1α的SUMO化修饰情况.实验结果显示:PM2.5暴露后,小鼠主动脉SUMO-1、HIF-1α、VEGF的表达上调;PM2.5暴露诱导了SUMO-1对HIF-1α的SUMO化修饰;低氧条件下SUMO-1敲低导致HIF-1α表达的下调.结果提示PM2.5暴露通过上调细胞中SUMO-1的表达,稳定或者上调HIF-1α的表达,进而影响血管内皮生长因子(VEGF)的表达,造成动脉粥样硬化斑块的不稳定.
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Key words
PM2.5 exposure,SUMO-1,HIF-1 alpha,Vascular endothelial growth factor (VEGF)
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