2-氯-N-苯基苯甲酰胺的合成及其抑菌活性研究

LUO Qing-chun,TIAN Jia-yuan, LIU Sen, LIU Han, CHEN Zhi-wei,XIANG Wen-liang

Journal of Xihua University(Natural Science Edition)（2011）

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Abstract

目的:合成2-氯-N-苯基苯甲酰胺,并测定其对水稻纹枯病菌(Rhizoctonia solani)和油菜菌核病菌(Sclerotiua sclerotiorum)的抑菌活性.方法:以2-氯苯甲酰氯和苯胺为原料,采用酰卤的胺解法合成2-氯-N-苯基苯甲酰胺,并通过IR,1H NMR进行结构确认.以多菌灵为对照,采用平板生长速率法测定其对水稻纹枯病菌和油菜菌核病菌菌丝的抑制率.结果:2-氯-N-苯基苯甲酰胺对水稻纹枯病菌和油菜菌核病菌均有较好的抑菌活性,其抑制中浓度IC50分别为5.00,6.38 mg/L.结论:合成的2-氯-N-苯基苯甲酰胺为研究和开发高效、低毒、对非靶标生物安全的新型植物病原真菌农药奠定了较好基础.

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Key words

antifungal activity,synthesis,chloro-n-phenylbenzamide

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