液相色谱-串联质谱法测定尿液中的泛酸
Journal of Instrumental Analysis(2017)
Abstract
该文建立了检测尿液中泛酸含量的液相色谱-串联质谱(HPLC-MS/MS)方法,尿液经过离心、稀释后,采用ACPUITY UPLC SS T3(2.1 mm ×l00 mm,1.8lμm)色谱柱进行分离,电喷雾正离子模式电离,多反应监测模式进行检测,方法的线性关系良好(r =0.999 3),方法检出限为0.46 ng/mL,回收率为87.9%~95.3%,相对标准偏差(RSD)为2.5%~13.0%.该方法具有灵敏度高、分析时间短等特点,可用于尿液中泛酸含量的分析.
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Key words
liquid chromatography tandem mass spectrometry,urine,pantothenic acid,biomonitoring
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