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Progress In Non-Classical Antitumor Platinum Drugs

Lh Wang,Y Liu,Qd You,Sh Gou

PROGRESS IN CHEMISTRY（2004）

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Abstract
The progress in non-classical antitumor platinum drugs are reviewed. These potential drugs include orally active platinum( IV ) complexes, sterically hindered platinum( II ) complexes, trans-platinum( II, IV ) complexes, multinuclear platinum( II ) complexes and sulphur-containing platinum( II ) complexes. Their antitumor mechanisms, advantages overcoming cisplatin resistance and clinical trials are summarized.
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Key words
antitumor platinum drugs, non-classical structure, activity relationship, orally activity, cross-resistance, antitumor mechanism
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