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新型尿酸转运蛋白1(URAT1)抑制剂的设计、合成及生物活性研究

Chao XIA,Bo WEI,Yu SHI,Yi-liang LI,Song-qing WANG

Chemical Reagents（2015）

Cited 1|Views8
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Abstract
根据Ardea Biosciences公司的Ⅲ期临床URAT1抑制剂Lesinuard的结构设计了两类新型化合物,并完成了22个目标化合物的合成及生物活性研究,最终将生物活性最好的化合物([1-(3,4-二氟苯基)-1H-咪唑[4,5-c]吡啶-2-磺酰基]乙酸叔丁酯)确定为URAT1抑制剂的新型先导化合物.
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Key words
URAT1,URAT1 inhibitor,uric acid,gout
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