胡蜂蜂毒肽的固相合成

Jing DING,Yu ZHAO,Cheng REN,Lian ZHANG, Jing-wen HU,Wei-zhen FANG,Qun LU

Chinese Journal of Synthetic Chemistry（2020）

Cited 0|Views6

No score

Abstract

采用Fmoc固相合成策略,合成了胡蜂蜂毒肽(COOH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2).以Wang树脂为载体,HBTU-HOBt为缩合剂,按照其氨基酸序列依次缩合,最终用切割试剂将其从树脂上切割下来,得到粗肽,经RP-HPLC纯化得到目标肽,纯度97.6％.经HR-MS (EI)分析,确定产物为胡蜂蜂毒肽.

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined