Search
ChatPaper
AI Writing
analysis
Analysis
编组
Open Data
more
More
RankingsMust ReadingJournal&ConferenceAI TRAI HistoryMaster Reading TreeXiaomai's Star TalentsTrajectoryTalentNDI TrackerAI sign LanguageOpen
VIPCreated with Sketch.

抗抑郁药盐酸度洛西汀的合成及其中间体杂质的研究

Cheng-yu JI, Tong-jie XIE,Jia-jia WU,Liang-xiu MA,Zhi-kui HAO,Jian-bo YAN,Feng XU

Chinese Journal of Synthetic Chemistry（2018）

Cited 1|Views2
No score
Abstract
以乙酰噻吩和甲胺盐酸盐为原料,经Mannich缩合、酶法还原和缩合共3步反应合成了抗抑郁药盐酸度洛西汀,总收率50.6%,并对第一步反应中的3个杂质进行了1H NMR, 13C NMR和MS(ESI)分析,确证为1,5-二(噻吩-2-基)戊烷二酮,3-乙氧基-1-(噻吩-2-基)-1-丙酮和N,N-二[(噻吩-2-基)丙酮-1-基]甲胺.并对反应机理进行了探讨.
More
Translated text
Key words
acetylthiophene,Duloxetine,enzymatic method,impurity,synthesis
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined