4-羟丁基缩水甘油醚的合成
Chinese Journal of Synthetic Chemistry（2017）
Abstract
以1,4-丁二醇(BDO)和环氧氯丙烷(ECH)为原料,经一步法合成了丙烯酸羟丁基缩水甘油醚中间体4-羟丁基缩水甘油醚(4-HBGE),其结构经1H NMR和MS(ESI)确证.对反应条件进行了优化,最佳反应条件为:BDO 0.1 mol,四丁基溴化铵(5 wt%)为催化剂,n(ECH)∶n(BDO)为1 ∶2, n(NaOH) ∶n(BDO)=1 ∶1.5,甲苯/水(V/V=1/1)为溶剂,于40 ℃反应6 h,经二级萃取法提纯,4-HBGE收率和纯度分别为69.5%和97.6%.
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Key words
4-butylene glycol,epichlorohydrin,one-step method,phase transfer catalyst,synthesis,4-hydroxybutyl acrylate glycidylether,4-hydroxybutyl glycidylether
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