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延龄草苷对过氧化氢诱导的PC12细胞氧化损伤和炎症因子表达的影响

Jian-mei GAO,Fan XU,Ming LEI,Shuang LIU,Qi-hai GONG

Natural Product Research and Development（2017）

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Abstract
探讨延龄草苷对过氧化氢(H2O2)诱导的PC12细胞氧化损伤和炎症因子表达的影响.采用MTT法和LDH活性测定观察延龄草苷对PC12细胞模型的影响,采用相关试剂盒检测活性氧(ROS)和丙二醛(MDA)含量,超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活力,Western blot检测Sirt1、NF-κB和TNF-d的蛋白表达.延龄草苷(5～20 μM)能够显著提高H2O2损伤的PC12细胞的活力,提高细胞抗氧化能力,并上调Sirt1的表达,下调NF-κB和TNF-α.的表达,其保护作用可能与提高抗氧化能力,降低炎症因子损伤,调控Sirt1/NF-κB信号通路有关.
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Key words
trillin,PC12 cells,oxidative stress,inflammatory factor
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