连翘提取物和连翘挥发油对酵母致热大鼠的解热机制研究
Natural Product Research and Development（2017）
Abstract
对比观察连翘提取物和连翘挥发油对酵母菌所致发热大鼠的解热效应和机制.酵母菌皮下注射复制大鼠发热模型.测基础体温后,随机分为空白组、模型组、连翘提取物组(25生药g/kg)和连翘挥发油组(26.7生药g/kg)四组,动态观察给药后大鼠2h体温和下丘脑cAMP和PGE2含量.结果表明连翘提取物和连翘挥发油均可显著降低酵母致热大鼠的体温(P＜0.01或P＜0.05),能显著降低下丘脑中cAMP(P ＜0.05)含量;另外连翘提取物能显著降低下丘脑中PGE2(P＜0.05)含量.连翘提取物有下调下丘脑中cAMP、PGE2作用,连翘挥发油通过下调下丘脑cAMP发挥解热作用,可用于临床发热的对症治疗.
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Key words
Forsythia suspensa extract,forsythia oil,antipyretic mechanism,cAMP,PGE2
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