链霉菌Streptomyces sp.HS-NF-496中两个Anthrabenzoxocinone类化合物

Min-na DU,Nan JIANG,Ling-jian ZHANG,Hang-feng ZHANG,Huan QI,Hui ZHANG,Ji-dong WANG

Natural Product Research and Development（2017）

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Abstract

对链霉菌Streptomyces sp.HS-NF-496的次级代谢产物进行了研究,分离得到两个化合物,经1D和2DNMR、CD、MS波谱分析及与文献数据比较,鉴定它们分别为(-)-(6R,16R)10-Cl-ABX(1)和(-)-(6R,16R)-ABX(2).对两个化合物的细胞毒活性和抗菌活性评价实验结果表明:化合物1和2对人肺腺癌A549细胞,人结肠癌HCT-116细胞和人神经癌SF-268细胞表现出较弱的细胞毒活性;化合物1和2对绿脓杆菌,金黄色葡萄球菌,枯草芽胞杆菌和耐甲氧西林金黄色葡萄球菌表现出中等强度的抗菌活性.本文首次报道了化合物1的绝对构型.

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Key words

Streptomyces sp.,anthrabenzoxocinones,cytotoxicity,antibacterial activity

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