结核分枝杆菌逃逸巨噬细胞杀伤机制的研究进展

Chinese Journal of Microbiology and Immunology(2020)

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Abstract
结核分枝杆菌( Mycobacterium tuberculosis, MTB)的致病机制一直是结核病的研究重点。MTB的致病性,特别是潜伏感染与其能逃逸免疫杀伤的特性密切相关。巨噬细胞是人体中的重要免疫细胞之一,但MTB逃逸巨噬细胞的杀伤机制仍不甚清楚。前沿研究发现MTB对巨噬细胞相关受体、吞噬溶酶体、氧化应激、凋亡、自噬及焦亡等诸多方面存在影响,从而介导逃逸其杀伤作用。本文将对此加以综述,以期为后续研究者提供更多参考。
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Key words
Mycobacterium tuberculosis,Macrophages,Escape mechanism
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