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用皂土法制造型特异性肉毒诊断血清

张雪平,何星,田盛举, 薛峰, 马占恒,王荫椿

PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY（2005）

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Abstract
用皂土为载体与类毒素结合方法及破伤风类毒素抗原抗体絮状反应方法去除A、B、C、D、E、F型肉毒抗血清原料中的异型和异种抗毒素(破伤风抗毒素).制备的A、B、C、D、E、F型肉毒诊断血清每1ml 均能中和相应型的肉毒毒素10000LD50以上,而中和异型肉毒毒素或破伤风毒素均低于5 LD50;A、B、C、D、E、F各型混合后的混合型血清每1ml 能中和各型肉毒毒素亦大于10000 LD50,中和破伤风毒素低于5 LD50,即效价和特异性符合规程要求.
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Key words
botulinum toxin,diagnostic sera
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