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MicroRNAs参与调控中枢神经系统的发育及脊髓损伤修复

Hongjun Zou,Xin Gao,Jian Zhang,Ya Ding,Aihua Gong,Jingbo Liu

Chinese Journal of Cell Biology（2014）

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Abstract
microRNAs(miRNAs)不仅参与神经系统的生长发育、功能完善,还参与脊髓损伤病理及损伤后修复过程.miRNAs能使中枢神经系统按正确的时序性和空间性顺序进行发育和分化,在维持生物体记忆及生物钟方面起着重要作用.miRNAs异常表达同脊髓损伤病理过程相关.目前,体内及体外实验均已证实,miRNAs不仅能够维持神经千细胞增殖,而且可以促进神经元轴突伸长,从而为脊髓损伤的治疗带来新的治疗策略.
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Key words
microRNAs,CNS developement,stem cell proliferation,neuron regeneration,spinal cord injury
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