人C1酯酶抑制剂的研究进展
Chinese Journal of Biologicals（2017）
Abstract
C1酯酶抑制剂(C1 esterase inhibitor,C1-INH),又称C1抑制物(C1 inhibitor),是目前已知的唯一一种既能通过经典途径,又能通过凝集素途径对补体系统进行调节的血浆蛋白酶抑制物,其在补体系统、激肽释放酶-激肽系统、纤溶系统和凝血系统中发挥重要的调节作用.目前有4种C 1-INH浓缩制剂批准上市,均用于治疗或预防遗传性血管性水肿(hereditary angioedema,HAE).本文就C1-INH的生化性质与生理功能、相关疾病与临床研究、C1-INH浓缩制剂的制备工艺及产品比较作一综述.
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Key words
C1 esterase inhibitor,C1-INH concentrates,Hereditary angioedema
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