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骨髓间充质干细胞外泌体对SD大鼠早衰卵巢的影响

Zheng ZHOU, Bo DU,Xue FAN,Nan LI,Hao AI

China Sciencepaper（2018）

Cited 3|Views8
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Abstract
为探讨大鼠骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)外泌体(exsomes)是否可以改善顺铂致卵巢早衰(premature ovarian failure,POF)大鼠的卵巢功能,采用全骨髓培养法培养大鼠BMSCs,传代提取外泌体并进行鉴定;SD大鼠随机分组进行动物实验,ELISA法测定血清卵泡激素(follicle stimulating houmone,FSH)、雌二醇(E2)及计数各级卵泡数检测大鼠卵巢功能.结果表明:经外泌体治疗后,大鼠血清中E2上升、FSH水平下降,接近正常水平,各级卵泡数目均明显增加,与模型组比较差异显著(P＜0.05).BMSCs外泌体可通过调节血清中各激素含量,促进卵泡发育,降低顺铂对卵巢的损害,修复卵巢功能.
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