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一条新的人类组氨酰tRNA合成酶类似物全长cDNA的克隆及表达谱分析

孟宪芳,陈金中,杨泉胜,王曙,周光云,应康,谢毅,毛裕民

JOURNAL OF FUDAN UNIVERSITY(NATURAL SCIENCE)（2002）

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Abstract
从人胎脑文库中克隆到一条长为1 219 bp的cDNA,它编码23.4 ku的肽链.该肽链与葡萄球菌组氨酰tRNA合成酶N端同源58%.利用human genomic blast可将其定位于20p¨Northem杂交显示胎脑中有一约1.5kb的单一条带.基因芯片杂交分析表明,其在肺癌和前列腺癌组织中表达较高.绿荧光蛋白亚细胞定位技术显示该蛋白存在于COS7细胞的细胞质中.
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