石榴酸和α-酮酸对人恶性黑色素瘤A375细胞的细胞毒性作用
Acta Nutrimenta Sinica(2015)
Abstract
石榴酸(punicic acid,PA,9c,11t,13c-18:3)和α-酮酸(α-eleostearic acid,α-ESA,9c,11t,13t-18:3)是两种最重要的共轭亚麻酸(conjugated linolenic acid,CLN)异构体CLN异构体[1]。体内和体外研究表明,共轭亚麻酸(conjugated linolenic acid,CLN)有较强体内和体外抗肿瘤作用[2-3],且CLN单体是抑制各种肿瘤细胞生长强效抑制剂[4]。石榴籽油是一种安全有效预防皮肤癌的化学预防剂,摄入5%的石榴籽油可显著降低皮肤肿瘤的发生率和多样化[5]。PA和α-ESA均可在体内代谢为9c,11t共轭亚油酸(9c,11t-conjugated linoleic acid,9c,11t- CLA)[6-7],而CLA单独或者与亚油酸或γ-亚麻酸混合使用均可以强烈改善小鼠皮肤的组分[8]。
MoreKey words
human skin cancer cells (A375),punicic acid,α-eleostearic acid,cytotoxic effect,fatty acids
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