雷替曲塞对比5-FU联合伊立替康治疗晚期结肠癌的临床观察
Chinese Community Doctors(2015)
Abstract
目的:探讨雷替曲塞对比5-FU联合伊立替康治疗晚期结肠癌的疗效及安全性。方法:将晚期结肠癌患者64例随机平分为两组,观察组予雷替曲赛联合伊立替康化疗,对照组予5-FU联合伊立替康化疗。均21 d 为1个周期,4个周期后评价疗效。结果:两组临床获益率、不良反应发生率和住院天数比较差异有统计学意义(P<0.05)。结论:雷替曲塞联合伊立替康治疗晚期结肠癌有效,可减少静脉暴露时间,缩短住院天数,不良反应可耐受,临床获益优于以5-FU为基础的化疗方案。
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