胚胎培养液中sHLA-G表达水平与临床结局相关性的研究
Chinese Journal of Birth Health & Heredity(2020)
Abstract
目的 探讨胚胎培养液中可溶性的白细胞抗原-G(Soluble Human Leukocyte Antigen-G,sHLA-G)的表达与早期胚胎发育的关系及其对IVF-ET妊娠结局的影响.方法 留取第3天移植及冷冻后的胚胎培养液,将微滴装入EP管置于-80冻存.ELISA法检测sHLA-G的表达水平.结果 优质胚胎对应胚胎培养液中优质胚胎表达水平均明显高于非优质胚胎,差异有统计学意义(P<0.05).妊娠组胚胎培养液中sHLA-G的表达水平显著高于非妊娠组,差异有统计学意义(P<0.05).结论 胚胎培养液中sHLA-G的表达水平与早期胚胎发育潜能及临床妊娠率呈现一定的相关性,可作为预测胚胎质量及妊娠结局的参考指标之一.
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