1、6二磷酸果糖治疗新生儿HIE病疗效观察及预后探讨
CHINESE JOURNAL OF BIRTH HEALTH & HERDITY(2001)
Abstract
探讨1、6二磷酸果糖(FDP)治疗新生儿缺氧缺血性脑病(HIE)的疗效及预后.应用FDP治疗115例HIE患儿,剂量200-250mg/kg/日,半小时内缓慢滴注,每日1次,7天1疗程.轻者用1疗程,重者用2疗程.结果表明:FDP能够缩短患儿的意识障碍时间,促进新生儿原始反射的恢复,与对照组相比差异显著P<0.05.通过对6个月-2岁小儿的随访,对照组后遗症发生率28%,治疗组后遗症发生率13.2%,明显低于对照组,差异显著(x2=4.71,P<0 05).结论:外源性FDP能够显著的改善HIE患儿临床症状,改善预后,减少后遗症的发生.
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