福建省沿海与内陆居民胃黏膜功能状态调查

Tiehui CHEN,Xiuquan LIN,Wenling ZHONG,Jianshun CHEN,Renzhong CHEN,Song LIN,Bangchang DENG,Xiaoling WU,Chun WU, Yihui CHEN, Feng QIU,Xiangquan XIE,Sihan WU,Danfeng LIU,Kuicheng ZHENG

Strait Journal of Preventive Medicine（2020）

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Abstract

目的了解福建省沿海与内陆居民胃黏膜功能状态.方法采用多阶段随机抽样法,在沿海和内陆地区5个县(市、区)抽取1 410名居民开展问卷调查,用ELISA法检测血清胃蛋白酶原Ⅰ、Ⅱ和Hp-IgG水平,计算PGR(pepsinogen ratio),比较沿海与内陆居民胃黏膜功能状态.结果沿海居民血清PGR水平低于内陆,血清PGR异常率高于内陆,胃癌血清学指标筛查阳性率高于内陆,PGR水平异常风险是内陆的3.33倍,PG Ⅰ合并PGR水平异常风险是内陆的1.42倍.结论福建省沿海居民胃黏膜功能水平低于内陆,在沿海地区开展萎缩性胃炎及早期胃癌筛查,对降低胃癌发病率有较大的现实意义.

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