盐析法制备小檗碱壳聚糖纳米载药微球
Chinese Journal of Experimental Traditional Medical Formulae（2014）
Abstract
目的:探索制备小檗碱壳聚糖载药纳米微球颗粒的新方法及关键技术.方法:采用盐析法,通过三聚磷酸钠交联制备小檗碱壳聚糖纳米载药微球,测定载药微球的包封率,观察其扫描电镜图及红外光谱.结果:小檗碱颗粒粒径分布于400～500 nm,经壳聚糖包裹的小檗碱纳米颗粒形状规则,具有核-壳结构,平均粒径约500 nm,包封率约70％.结论:壳聚糖包裹的小檗碱颗粒具有均一的纳米粒径和良好的包封率,为小檗碱缓释用药和靶向给药设计提供参考.
MoreKey words
salt precipitation,berberine,chitosan,nanoparticles,scanning electron micrographs,infrared spectroscopy,particle size distribution
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