活骨注射液对SANFH家兔BMP-2及VEGF表达的影响

Information on Traditional Chinese Medicine(2017)

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Abstract
目的:通过建立SANFH家兔模型,探讨活骨注射液髋关节注射治疗激素型股骨头坏死(steroid-induced avascular necrosis of femoral head,SANFH)中股骨头局部血管内皮生长因子(vascular endothelial growth factor, VEGF)及骨形态发生蛋白2(bone morphogenetic protein 2,BMP-2)表达的变化及意义.方法:选择健康成年雄性新西兰大白兔72只,空白组18只无特殊处置,其余家兔采用马血清加激素法造模.将造模成功家兔随机分为模型组、对照组与治疗组3组,每组18只.模型组家兔双侧髋关节每日给予生理盐水关节腔注射,对照组给予等量冠心宁关节腔注射治疗,治疗组给予等量活骨注射液双髋关节注射治疗.2、5、8周各处死6只新西兰大白兔,取双侧股骨头,免疫组化法检测BMP-2及VEGF的蛋白表达,RT-PCT法检测VEGF mRNA表达变化.结果:活骨注射液在SANFH治疗的过程中对BMP-2及VEGF的表达有影响(P<0.05),具有统计学意义.结论:活骨注射液在SANFH治疗2周后可使BMP-2及VEGF的表达上调,其中8周达到最佳疗效.
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