子宫内膜异位症相关信号通路及中医药治疗对策的研究进展

World Journal of Integrated Traditional and Western Medicine(2017)

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Abstract
子宫内膜异位症(endometriosis,EMs)好发于育龄期女性,在不孕症患者当中,其发病率高达45%~50%,已成为不孕症的主要病因之一,近年来,国内外研究表明与EMs发生发展相关的信号通路主要有丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)通路、磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶(phosphatidyl-inositol 3-kinase/serine-threonine kinase,PI3K/AKT)通路、Wnt 蛋白/β-连环蛋白(Wnt/β-catenin)通路、转化生长因子-β/Smad 蛋白(transforming growth factor-β/drosophila mothers against decapentaplegic protein,TGF-β/Smad)通路、核转录因子kappa B(NF-κB)通路等,并有学者从上述通路探讨了中医药治疗EMs的疗效机制,文章就这5条信号通路与EMs发生发展关系以及中医药治疗对策的研究进展进行一简要综述.
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