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从“亢害承制”理论探讨糖脂毒性下β细胞损伤及其ceRNA调控网络

Zebiao CAO,Chuang LIU,Baohua WANG,Saimei LI

Journal of Traditional Chinese Medicine（2020）

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Abstract
“亢害承制”理论是中医学认识人体生理制化、病理失衡及指导调燮用药的重要法则.该理论可以概括糖脂与胰岛β细胞之间“亢而自制免其害”的相辅相成生理良性循环,也可以阐明“亢而失制受其害”的糖脂毒性下胰岛β细胞损伤的病理恶性循环,并与“lncRNA/circRNA克miRNA,miRNA克mRNA,lncRNA/circRNA生mRNA”的ceRNA生克制化网络相似.在这一认识指导下,2型糖尿病可采取祛邪制“亢”和扶正防“害”的思路进行临床治疗和科学研究.
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