经皮吸收制剂三七膜剂的制备工艺研究

Shijun LIU, Pan ZHANG,Zhishu TANG,Yu ZHANG,Zhongxing SONG,Chunli CUI,Hongbo LIU,Hongbo XU,Yanni LIANG

Western Journal of Traditional Chinese Medicine（2020）

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Abstract

目的:考察经皮吸收制剂三七膜剂的制备工艺.方法:用聚乙烯醇05-88与聚乙烯醇17-88作为成膜材料,甘油作为增塑剂,吐温80作为表面活性剂在单因素实验的基础上用正交实验L9(33)进行基质处方的筛选,考察制成膜剂的柔软性、光滑性、色泽透明度、均匀性,最后得出最佳基质处方比例.结果:经筛选得出的最佳基质处方为:PVA05-881.0 g,PVA17-883.0 g,甘油4.0 g,吐温802.0 g.结论:通过正交实验筛选所得的基质中加入三七提取物后其柔软性、光滑性、色泽透明度、均匀性较好;该三七膜剂的制备工艺简单、可行.

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