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麝香乌龙丸对RA患者外周血miR-146a、miR-130及miR-223表达水平的影响

Zhi-wen WANG,Song-song WANG,Jian-mei CUI,Ying CAO,Ding-jie XU,Qiang YUAN,Xiao-han YU,Chen-hui REN,Wei-jing ZHONG

Chinese Traditional Patent Medicine（2017）

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Abstract
目的 探讨麝香乌龙丸(人工麝香、制川乌、地龙等)含药血清对类风湿关节炎(RA)患者外周血单个核细胞(PBMCs)中miR-146a、miR-130、miR-223表达水平的影响.方法 从30例RA患者血液中提取PBMCs,将细胞分为3组,空白对照组、空白血清组、麝香乌龙丸含药血清组.48 h后提取总RNA,采用实时荧光定量聚合酶链式反应(RT-PCR)法检测3种miR的表达水平.结果 与空白血清组相比,麝香乌龙丸含药血清组miR-146a、miR-130、miR-223表达水平显著降低(P＜0.01).结论 麝香乌龙丸可通过下调PBMCs中miR-223、miR-130、miR-146a表达水平来抑制RA患者炎症.
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Key words
Shexiang Wulong Pills,rheumatoid arthritis (RA),miR-146a,miR-130,miR-223
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