白头翁总皂苷结肠定位固体分散体制备
Chinese Traditional Patent Medicine（2015）
Abstract
目的 制备白头翁总皂苷结肠定位固体分散体.方法 采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析.结果 SEM和IR分析结果显示白头翁总皂苷和Eudragit S100形成了固体分散体.体外释放度结果显示载药量在20％时指标成分在pH 1.0溶液中2h基本不释放,在pH 6.8溶液中4h累积释放度小于16％,在pH7.8溶液中2h累积释放大于86％.结论 所制备的固体分散体达到了结肠定位的效果.
MoreKey words
total saponins from Pulsatilla chinensis,colon-specific,solid dispersion,in vitro release,scanning electron microscopy (SEM),Fourier transform infrared spectroscopy (FTIR)
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