香苓开胃方对功能性消化不良大鼠干预效应及机制研究
China Journal of Traditional Chinese Medicine and Pharmacy（2020）
Abstract
目的:观察香苓开胃方对功能性消化不良大鼠(FD)干预效应及机制.方法:测定FD大鼠肠推进率,酶联免疫吸附法(ELISA)检测血清胃动素(MTL)、胃饥饿素(Ghrelin)和胃泌素(GAS)水平,实时定量PCR检测与分析瘦素(Leptin)、闭合蛋白(Occludin)、络氨酸激酶(C-kit) mRNA表达.结果:香苓开胃方高剂量药物干预显著促进肝郁脾虚模型FD大鼠肠推进率(P＜0.05);显著提高大鼠血清MTL(P＜0.05);显著下调FD大鼠胃组织Leptin mRNA表达(P＜0.05)和提高FD大鼠胃组织Occludin mRNA表达(P＜0.05).结论:香苓开胃方对FD具有显著的治疗作用,其机制与促进胃肠运动有关、调节胃肠激素等有关.
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