温阳逐水方外敷联合顺铂腔内灌注治疗恶性胸水的临床研究

Shaoquan XIONG,Yaling LI,yang YANG,Tingting SONG,Lijuan WANG,Rui CAI,Qiuyue LUO,Qian DING,Guoyu WU,Chenshi HE

Liaoning Journal of Traditional Chinese Medicine（2019）

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Abstract

目的:观察温阳逐水方外敷联合化疗腔内灌注治疗恶性胸水疗效.方法:66例大中量胸腔积液的肺癌患者,随机分为试验组、对照组,每组33例.对照组120 mg顺铂分两次胸腔灌注,试验组顺铂胸腔灌注的基础上加用温阳逐水方外敷.疗效评价:胸水客观缓解率(ORR)、无进展生存期(PFS)、临床症状改善等.结果:试验组和对照组ORR分别是81.8％和72.7％ (P ＞0.05),胸水中位PFS分别是5.2月和3.2月(P＜0.05),主要临床症状(乏力、咳嗽、胸痛、气紧)分析,治疗1个月后试验组乏力改善明显优于对照组(P＜0.05),其余症状改善无明显差异(P＞0.05),3个月后胸水相关临床症状试验组改善均优于对照组(P＜0.05).结论:温阳逐水方外敷联合顺铂腔内灌注,可明显延长胸水PFS,缓解临床症状,值得临床推广.

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