苦参碱自微乳在大鼠体内药动学及组织分布

Hui LYU,Tingting SU,Yanan ZHANG, Xuemei WANG,Ying MENG,Chunsheng FU

Journal of Liaoning University of Traditional Chinese Medicine（2018）

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Abstract

目的:考察大鼠分别灌胃苦参碱自微乳和原料药后药动学参数及组织分布情况.方法:大鼠分别灌胃苦参碱自微乳和原料药, 通过高效液相色谱法测定大鼠血浆及各组织中苦参碱浓度, 比较两者灌胃后药动学参数和体内分布特点.结果:在药动学研究中, 苦参碱自微乳组中AUC是原料药组的2.2倍, t1/2由3.655 h延长到3.845 h.在组织分布研究中, 苦参碱自微乳在大鼠肝组织中的含量显著提高, 其次是脾、肾、心, 在肺、脑中含量较少.结论:苦参碱制成自微乳后可以提高其生物利用度, 在一定程度上延长苦参碱在动物体内循环时间, 具有一定肝靶向作用.

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Key words

matrine,self-microemulsion,pharmacokinetics,tissue distribution

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