咳喘方对支气管哮喘模型大鼠气道重塑的干预作用
Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai(2017)
Abstract
目的:探讨咳喘方对支气管哮喘模型大鼠气道重塑的干预作用.方法:将30只SD雄性大鼠分为对照组、模型组、中药组,每组10只.除对照组外均行支气管哮喘造模;中药组予咳喘方灌胃,其余两组予0.9% NaCl注射液灌胃,疗程3周.采用免疫组化法检测各组大鼠肺组织转化生长因子-β1(TGF-β1)的表达;并取肺组织经HE染色进行病理观察,图像分析测定其气道壁总面积(Wat)、管壁平滑肌面积(Wam)、支气管底膜周径(Pbm)、支气管周围胶原纤维组织面积(Wac)的数值.结果:模型组TGF-β1表达较对照组明显升高(P<0.01);中药组TGF-β1计数较模型组明显降低(P<0.01).模型组Wat、Warm、Wac水平较对照组明显升高(P<0.01);中药组Wat、Warm、Wac水平较模型组明显降低(P<0.01).结论:咳喘方可抑制支气管哮喘大鼠肺组织TGF-β1表达和气管壁增厚.
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Key words
Kechuan Decoction,asthma,airway remodeling,rat
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