复合因素致气虚血瘀证模型的制备
Pharmacology and Clinics of Chinese Materia Medica(2013)
Abstract
目的:探索气虚血瘀证动物模型的制作方法.方法:采用"饥饿+高脂+肾上腺素"复合多因素制备气虚血瘀证模型.结果:模型组家兔表现为蜷缩少动、精神不振、爪尾部紫暗等症状;血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)显著升高、血浆内皮素(ET)升高,血管紧张素Ⅱ(AngⅡ)升高,与正常组及对照组比较有显著性差异.结论:上述方法建立气虚血瘀证家兔模型,符合中医证侯特点,具有一定的理论和实践意义.
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