Abstract 12579: Sirt2 Contributes to the Development of Heart Failure Through a Nrf2 Dependent Pathway

Xiaoyan Yang,Meng Shang,Christine Kamide,Chunlei Chen,Seong Hoon Park,Rongxue Wu,Ting Liu,Athanassios Vassilopoulos,Hossein Ardehali

Circulation（2016）

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摘要

Introduction: Heart failure is associated with a change in cardiac energy metabolism and increased oxidative stress. Sirtuins (SIRTs) are NAD+-dependent deacetylases, and critical regulators of ene...

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Heart failure,Reactive oxygen intermediates,Oxidative stress

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