参附注射液对C26结肠癌荷瘤小鼠恶病质状态改善作用的实验研究
CHINESE JOURNAL OF TRADITIONAL MEDICAL SCIENCE AND TECHNOLOGY(2012)
Abstract
目的:观察参附注射液对C26荷瘤小鼠恶病质状态的影响,并探讨其可能的作用机理.方法:建立BALB/C荷C26结肠癌小鼠恶病质模型,观察参附注射液对恶病质小鼠一般状态(如体重、摄食量、饮水量)的影响;检测小鼠血清TNF-α、TG、CHOL、ALB、BIB水平.结果:参附注射液能增加恶病质小鼠的摄食量及饮水量;抑制体重下降(P<0.05);降低TNF-α水平(P<0.05);降低血清TG、CHOL水平(P<0.05),升高血清ALB、BIB水平(P<0.05),与甲地孕酮组比较无明显差异(P>0.05).结论:参附注射液能改善荷瘤小鼠的恶病质状态,作用机理可能与调节TNF-α水平相关.
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