加味桃核承气汤对四氯化碳肝纤维化大鼠治疗作用的实验研究
CHINESE JOURNAL OF TRADITIONAL MEDICAL SCIENCE AND TECHNOLOGY(2008)
Abstract
目的:观察加味桃核承气汤对四氯化碳肝纤维化大鼠的治疗作用.方法:用四氯化碳诱导大鼠肝纤维化模型,随机分为6组,分刺灌胃给药.疗程8周;检测血清ALT、AST水平;用苦味酸-天狼红胶原染色方法进行半定量肝纤维化计分(SS).结果:模型对照组血清ALT、AST水平及肝纤维化SSS计分显著高于正常对照组,经加味桃核承气汤治疗后血清ALT、AST汀水平及肝纤雏化SSS计分显著下降.结论:加味桃核承气汤可使四氯化碳诱导的大鼠肝纤雏化程度显著减轻.
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