血脂康对肥胖相关性肾病大鼠脂联素、炎症因子及尿蛋白的影响
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine(2013)
Abstract
目的:观察血脂康对肥胖相关性肾病(ORG)大鼠脂联素、炎症因子及尿蛋白的影响,探讨血脂康对ORG大鼠肾脏保护作用机制。方法:雄性Wistar大鼠30只,随机分为正常组、模型组和血脂康组,每组10只,分别给予普通饲料、高脂饲料、高脂饲料+血脂康喂养12周,观察各组大鼠血清脂联素、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、24h尿蛋白水平及肾脏病理变化。结果:12周后,模型组大鼠血清脂联素水平降低,IL-6水平升高,尿蛋白排泄增加,与正常组比较,差异有统计学意义(P均<0.01),TNF-α水平虽有升高,但与正常组比较差异无统计学意义(P跃0.05),肾脏病理损害明显。血脂康组脂联素水平升高,IL-6水平下降,尿蛋白减少,与模型组比较,差异有统计学意义(P均<0.01),肾脏病理损害减轻。结论:血脂康可下调肥胖相关性肾病大鼠炎症因子IL-6表达,升高抗炎因子脂联素水平,减轻炎症反应,从而发挥肾脏保护作用。
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Key words
rats,obesity related glomerulopathy,adiponectin,inflammtary cytokines,Xuezhikang
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