圆齿野鸦椿醇提物抗炎、镇痛作用的研究
Guiding Journal of Traditional Chinese Medicine and Pharmacology(2018)
Abstract
目的:探讨圆齿野鸦椿醇提物的抗炎、镇痛活性.方法:制备圆齿野鸦椿果皮、枝条、叶片和种子的乙醇提取物,采用小鼠二甲苯致耳廓肿胀法和醋酸致小鼠腹腔毛细血管通透性增加法,观察圆齿野鸦椿醇提物的抗炎作用;采用小鼠热板法和冰醋酸扭体法,观察圆齿野鸦椿醇提物的镇痛作用.结果:与对照组比较,圆齿野鸦椿果皮、枝条、叶片和种子的乙醇提取物均可显著抑制二甲苯致小鼠的耳肿胀和醋酸所致的毛细管通透性增加,并能缓解由热板法和冰醋酸所致的疼痛(P<0.05),其中圆齿野鸦椿果皮醇提物的效果最好.结论:圆齿野鸦椿的乙醇提取物具有良好的抗炎、镇痛作用.
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