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地黄导痰汤制剂对血管性痴呆患者血清NO、ET-1、SOD及MDA的影响

Meng ZHANG,Xiao-lin SUI,Chun-yan ZHANG

Guiding Journal of Traditional Chinese Medicine and Pharmacology（2017）

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Abstract
目的:研究地黄导痰汤制剂对血管性痴呆患者血清NO、ET-1、SOD及MDA的影响.方法:将62例本病患者随机分为两组各31例.在基础治疗的基础上治疗组予地黄导痰汤制剂口服,对照组予尼莫地平片口服,疗程为12周.结果:两组患者治疗后血清NO均较治疗前增加(P＜0.05或P＜0.01),ET-1均较治疗前降低(P＜0.05或P＜0.01);治疗组治疗后血清NO高于对照组(P＜0.01),ET-1低于对照组(P＜0.01).治疗组患者治疗后血清SOD较治疗前增加(P＜0.05),血清MDA含量较治疗前降低(P＜0.05);治疗组治疗后血清SOD高于对照组(P＜0.01),血清MDA含量低于对照组(P＜0.01).结论:地黄导痰汤制剂可促进血管性痴呆患者内皮细胞释放血清NO,减少血清ET-1释放;增加血清SOD含量,减少血清MDA含量.
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Key words
vascular dementia,Dihuang Daotan preparation,serum NO,serum ET-1,serum SOD,serum MDA
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